Erhard Bieberich, PhD

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Erhard.Bieberich@uky.edu
Office: (859) 323-8079
Medical Science Building, MS 519
800 Rose St. Lexington, KY 40506

Position(s):

Professor

Affiliation(s):

Physiology

Interests / Specialties:

Lipid biochemistry (focus ceramide

a sphingolipid)

Stem cell research and brain development

Neurodegeneration (focus Alzheimer's Disease)

Bio / Education:

1986: MS in Biochemistry, University of Cologne, Germany
1990: PhD in Biochemistry, University of Cologne, Germany
1990-1996: Post-doctoral fellow at the Department of Physiol. Chemistry, University of Bonn, Germany
1996-2000: Instructor and then Assistant Professor (1999) at the Department of Biochemistry, Virginia Commonwealth
University, Richmond, VA
2000-2017: Assistant, Associate (2004), and then full Professor (2011, tenured) at the Department of Neuroscience and
Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA
2017: Full Professor at the Department of Physiology, University of Kentucky, Lexington, GA

Research Description:

Under construction

Grants:

Under construction

PubMed Publications:

Wang, G.;Spassieva, S.D.;Bieberich, E. "Ceramide and S1P Signaling in Embryonic Stem Cell Differentiation." Methods in molecular biology (Clifton, N.J.) (2017): [PubMed Link] | [ Full text ]
Burgert, A.;Schlegel, J.;Bécam, J.;Doose, S.;Bieberich, E.;Schubert-Unkmeir, A.;Sauer, M. "Characterization of Plasma Membrane Ceramides by Super-Resolution Microscopy." Angewandte Chemie (International ed. in English) 56, 22 (2017): 6131-6135. [PubMed Link] | [ Full text ]
Yue, H.Y.;Bieberich, E.;Xu, J. "Promotion of endocytosis efficiency through an ATP-independent mechanism at rat calyx of Held terminals." The Journal of physiology 595, 15 (2017): 5265-5284. [PubMed Link] | [ Full text ]
Helwa, I.;Cai, J.;Drewry, M.D.;Zimmerman, A.;Dinkins, M.B.;Khaled, M.L.;Seremwe, M.;Dismuke, W.M.;Bieberich, E.;Stamer, W.D.;Hamrick, M.W.;Liu, Y. "A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents." PloS one 12, 1 (2017): e0170628. [PubMed Link] | [ Full text ]
Dinkins, M.B.;Wang, G.;Bieberich, E. "Sphingolipid-Enriched Extracellular Vesicles and Alzheimer's Disease: A Decade of Research." Journal of Alzheimer's disease : JAD (2016): [PubMed Link] | [ Full text ]
Spassieva, S.;Bieberich, E. "Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease." Journal of neuroscience research 94, 11 (2016): 974-81. [PubMed Link] | [ Full text ]
Spassieva, S.D.;Ji, X.;Liu, Y.;Gable, K.;Bielawski, J.;Dunn, T.M.;Bieberich, E.;Zhao, L. "Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency." Proceedings of the National Academy of Sciences of the United States of America 113, 21 (2016): 5928-33. [PubMed Link] | [ Full text ]
Walter, T.;Collenburg, L.;Japtok, L.;Kleuser, B.;Schneider-Schaulies, S.;Müller, N.;Becam, J.;Schubert-Unkmeir, A.;Kong, J.N.;Bieberich, E.;Seibel, J. "Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells." Chemical communications (Cambridge, England) 52, 55 (2016): 8612-8614. [PubMed Link] | [ Full text ]
Dinkins, M.B.;Enasko, J.;Hernandez, C.;Wang, G.;Kong, J.;Helwa, I.;Liu, Y.;Terry AV, J.;Bieberich, E. "Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse." The Journal of neuroscience : the official journal of the Society for Neuroscience 36, 33 (2016): 8653-67. [PubMed Link] | [ Full text ]
Kong, J.N.;He, Q.;Wang, G.;Dasgupta, S.;Dinkins, M.B.;Zhu, G.;Kim, A.;Spassieva, S.;Bieberich, E. "Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells." International journal of cancer 137, 7 (2015): 1610-20. [PubMed Link] | [ Full text ]
Kong, J.N.;Hardin, K.;Dinkins, M.;Wang, G.;He, Q.;Mujadzic, T.;Zhu, G.;Bielawski, J.;Spassieva, S.;Bieberich, E. "Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3." Molecular biology of the cell 26, 24 (2015): 4451-65. [PubMed Link] | [ Full text ]
Dinkins, M.B.;Dasgupta, S.;Wang, G.;Zhu, G.;He, Q.;Kong, J.N.;Bieberich, E. "The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden." Journal of Alzheimer's disease : JAD 46, 1 (2015): 55-61. [PubMed Link] | [ Full text ]
He, Q.;Wang, G.;Wakade, S.;Dasgupta, S.;Dinkins, M.;Kong, J.N.;Spassieva, S.D.;Bieberich, E. "Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide." Molecular biology of the cell 25, 11 (2014): 1715-29. [PubMed Link] | [ Full text ]
Janes, K.;Little, J.W.;Li, C.;Bryant, L.;Chen, C.;Chen, Z.;Kamocki, K.;Doyle, T.;Snider, A.;Esposito, E.;Cuzzocrea, S.;Bieberich, E.;Obeid, L.;Petrache, I.;Nicol, G.;Neumann, W.L.;Salvemini, D. "The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1." The Journal of biological chemistry 289, 30 (2014): 21082-97. [PubMed Link] | [ Full text ]
Paschall, A.V.;Zimmerman, M.A.;Torres, C.M.;Yang, D.;Chen, M.R.;Li, X.;Bieberich, E.;Bai, A.;Bielawski, J.;Bielawska, A.;Liu, K. "Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression." BMC cancer 14, (2014): 24. [PubMed Link] | [ Full text ]
Bradley, E.;Zhao, X.;Wang, R.;Brann, D.;Bieberich, E.;Wang, G. "Low dose Hsp90 inhibitor 17AAG protects neural progenitor cells from ischemia induced death." Journal of cell communication and signaling 8, 4 (2014): 353-62. [PubMed Link] | [ Full text ]
Dinkins, M.B.;Dasgupta, S.;Wang, G.;Zhu, G.;Bieberich, E. "Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease." Neurobiology of aging 35, 8 (2014): 1792-800. [PubMed Link] | [ Full text ]
Bradley, E.;Dasgupta, S.;Jiang, X.;Zhao, X.;Zhu, G.;He, Q.;Dinkins, M.;Bieberich, E.;Wang, G. "Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration." PloS one 9, 10 (2014): e110119. [PubMed Link] | [ Full text ]
Bieberich, E. "Synthesis, Processing, and Function of N-glycans in N-glycoproteins." Advances in neurobiology 9, (2014): 47-70. [PubMed Link] |
Dasgupta, S.;Kong, J.;Bieberich, E. "Phytoceramide in vertebrate tissues: one step chromatography separation for molecular characterization of ceramide species." PloS one 8, 11 (2013): e80841. [PubMed Link] | [ Full text ]
Bieberich, E. "Introduction to the fractality principle of consciousness and the sentyon postulate." Cognitive computation 4, 1 (2012): 13-28. [PubMed Link] |
Wang, G.;Dinkins, M.;He, Q.;Zhu, G.;Poirier, C.;Campbell, A.;Mayer-Proschel, M.;Bieberich, E. "Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD)." The Journal of biological chemistry 287, 25 (2012): 21384-95. [PubMed Link] | [ Full text ]
Bieberich, E. "It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation." Neurochemical research 37, 6 (2012): 1208-29. [PubMed Link] | [ Full text ]
He, Q.;Wang, G.;Dasgupta, S.;Dinkins, M.;Zhu, G.;Bieberich, E. "Characterization of an apical ceramide-enriched compartment regulating ciliogenesis." Molecular biology of the cell 23, 16 (2012): 3156-66. [PubMed Link] | [ Full text ]
Bradley, E.;Bieberich, E.;Mivechi, N.F.;Tangpisuthipongsa, D.;Wang, G. "Regulation of embryonic stem cell pluripotency by heat shock protein 90." Stem cells (Dayton, Ohio) 30, 8 (2012): 1624-33. [PubMed Link] | [ Full text ]
Bieberich, E. "Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation." Methods in molecular biology (Clifton, N.J.) 874, (2012): 177-92. [PubMed Link] | [ Full text ]
Bieberich, E. "There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells." Neurochemical research 36, 9 (2011): 1601-11. [PubMed Link] | [ Full text ]
Spassieva, S.;Bieberich, E. "The gut-to-breast connection - interdependence of sterols and sphingolipids in multidrug resistance and breast cancer therapy." Anti-cancer agents in medicinal chemistry 11, 9 (2011): 882-90. [PubMed Link] | [ Full text ]
Bieberich, E. "Lipid vesicle-mediated affinity chromatography using magnetic activated cell sorting (LIMACS): a novel method to analyze protein-lipid interaction." Journal of visualized experiments : JoVE 50 (2011): [PubMed Link] | [ Full text ]
Bieberich, E. "Ceramide in stem cell differentiation and embryo development: novel functions of a topological cell-signaling lipid and the concept of ceramide compartments." Journal of lipids 2011, (2011): 610306. [PubMed Link] | [ Full text ]
Muscoli, C.;Doyle, T.;Dagostino, C.;Bryant, L.;Chen, Z.;Watkins, L.R.;Ryerse, J.;Bieberich, E.;Neumman, W.;Salvemini, D. "Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids." The Journal of neuroscience : the official journal of the Society for Neuroscience 30, 46 (2010): 15400-8. [PubMed Link] | [ Full text ]
Wang, G.;Bieberich, E. "Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development." Cell death & disease 1, (2010): e46. [PubMed Link] | [ Full text ]
Wang, G.;Krishnamurthy, K.;Bieberich, E. "Regulation of primary cilia formation by ceramide." Journal of lipid research 50, 10 (2009): 2103-10. [PubMed Link] | [ Full text ]
Wang, G.;Krishnamurthy, K.;Umapathy, N.S.;Verin, A.D.;Bieberich, E. "The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells." The Journal of biological chemistry 284, 21 (2009): 14469-75. [PubMed Link] | [ Full text ]
Brooks, Y.S.;Wang, G.;Yang, Z.;Smith, K.K.;Bieberich, E.;Ko, L. "Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation." The Journal of biological chemistry 284, 27 (2009): 18033-46. [PubMed Link] | [ Full text ]
Wang, G.;Silva, J.;Dasgupta, S.;Bieberich, E. "Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes." Glia 56, 4 (2008): 449-56. [PubMed Link] | [ Full text ]
Bieberich, E. "Ceramide signaling in cancer and stem cells." Future lipidology 3, 3 (2008): 273-300. [PubMed Link] |
Wang, G.;Krishnamurthy, K.;Chiang, Y.W.;Dasgupta, S.;Bieberich, E. "Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development." Journal of neurochemistry 106, 2 (2008): 718-33. [PubMed Link] | [ Full text ]
Ritter, E.;Perry, A.;Yu, J.;Wang, T.;Tang, L.;Bieberich, E. "Breast cancer cell-derived fibroblast growth factor 2 and vascular endothelial growth factor are chemoattractants for bone marrow stromal stem cells." Annals of surgery 247, 2 (2008): 310-4. [PubMed Link] | [ Full text ]
Krishnamurthy, K.;Wang, G.;Rokhfeld, D.;Bieberich, E. "Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide." Breast cancer research : BCR 10, 6 (2008): R106. [PubMed Link] | [ Full text ]
Bieberich, E. "Smart drugs for smarter stem cells: making SENSe (sphingolipid-enhanced neural stem cells) of ceramide." Neuro-Signals 16, 2-3 (2008): 124-39. [PubMed Link] | [ Full text ]
Krishnamurthy, K.;Wang, G.;Silva, J.;Condie, B.G.;Bieberich, E. "Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis." The Journal of biological chemistry 282, 5 (2007): 3379-90. [PubMed Link] | [ Full text ]
Krishnamurthy, K.;Dasgupta, S.;Bieberich, E. "Development and characterization of a novel anti-ceramide antibody." Journal of lipid research 48, 4 (2007): 968-75. [PubMed Link] | [ Full text ]
Wang, G.;Silva, J.;Krishnamurthy, K.;Bieberich, E. "A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells." Apoptosis : an international journal on programmed cell death 11, 3 (2006): 315-25. [PubMed Link] | [ Full text ]
Silva, J.;Dasgupta, S.;Wang, G.;Krishnamurthy, K.;Ritter, E.;Bieberich, E. "Lipids isolated from bone induce the migration of human breast cancer cells." Journal of lipid research 47, 4 (2006): 724-33. [PubMed Link] | [ Full text ]
Bieberich, E. "Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells." Analytical biochemistry 346, 1 (2005): 185-7. [PubMed Link] | [ Full text ]
Wang, G.;Silva, J.;Krishnamurthy, K.;Tran, E.;Condie, B.G.;Bieberich, E. "Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells." The Journal of biological chemistry 280, 28 (2005): 26415-24. [PubMed Link] | [ Full text ]
Bieberich, E.;Silva, J.;Wang, G.;Krishnamurthy, K.;Condie, B.G. "Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants." The Journal of cell biology 167, 4 (2004): 723-34. [PubMed Link] | [ Full text ]
Yu, R.K.;Bieberich, E.;Xia, T.;Zeng, G. "Regulation of ganglioside biosynthesis in the nervous system." Journal of lipid research 45, 5 (2004): 783-93. [PubMed Link] | [ Full text ]
Bieberich, E.;Anthony, G.E. "Neuronal differentiation and synapse formation of PC12 and embryonic stem cells on interdigitated microelectrode arrays: contact structures for neuron-to-electrode signal transmission (NEST)." Biosensors & bioelectronics 19, 8 (2004): 923-31. [PubMed Link] |
Slaughter, G.E.;Bieberich, E.;Wnek, G.E.;Wynne, K.J.;Guiseppi-Elie, A. "Improving neuron-to-electrode surface attachment via alkanethiol self-assembly: an alternating current impedance study." Langmuir : the ACS journal of surfaces and colloids 20, 17 (2004): 7189-200. [PubMed Link] | [ Full text ]
Bieberich, E. "Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis." Glycoconjugate journal 21, 6 (2004): 315-27. [PubMed Link] |
Tencomnao, T.;Kapitonov, D.;Bieberich, E.;Yu, R.K. "Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE." Glycoconjugate journal 20, 5 (2004): 339-51. [PubMed Link] |
Silva, J.;Beckedorf, A.;Bieberich, E. "Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells." The Journal of biological chemistry 278, 28 (2003): 25376-85. [PubMed Link] | [ Full text ]
Bieberich, E.;MacKinnon, S.;Silva, J.;Noggle, S.;Condie, B.G. "Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide." The Journal of cell biology 162, 3 (2003): 469-79. [PubMed Link] | [ Full text ]
Bieberich, E.;MacKinnon, S.;Silva, J.;Li, D.D.;Tencomnao, T.;Irwin, L.;Kapitonov, D.;Yu, R.K. "Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases." Biochemistry 41, 38 (2002): 11479-87. [PubMed Link] | [ Full text ]
Bieberich, E.;Hu, B.;Silva, J.;MacKinnon, S.;Yu, R.K.;Fillmore, H.;Broaddus, W.C.;Ottenbrite, R.M. "Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells." Cancer letters 181, 1 (2002): 55-64. [PubMed Link] | [ Full text ]
Bieberich, E. "Recurrent fractal neural networks: a strategy for the exchange of local and global information processing in the brain." Bio Systems 66, 3 (2002): 145-64. [PubMed Link] | [ Full text ]
Bieberich, E.;MacKinnon, S.;Silva, J.;Yu, R.K. "Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides." The Journal of biological chemistry 276, 48 (2001): 44396-404. [PubMed Link] | [ Full text ]
Yu, R.K.;Bieberich, E. "Regulation of glycosyltransferases in ganglioside biosynthesis by phosphorylation and dephosphorylation." Molecular and cellular endocrinology 177, 1-2 (2001): 19-24. [PubMed Link] | [ Full text ]
Liour, S.S.;Jones, M.Z.;Suzuki, M.;Bieberich, E.;Yu, R.K. "Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID." Molecular genetics and metabolism 72, 3 (2001): 239-47. [PubMed Link] | [ Full text ]
Ren, S.;Kambe, N.;Du, Z.;Li, Y.;Xia, H.Z.;Kambe, M.;Bieberich, E.;Pozez, A.;Grimes, M.;Yu, R.K.;Irani, A.M.;Schwartz, L.B. "Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells." The Journal of allergy and clinical immunology 107, 2 (2001): 322-30. [PubMed Link] | [ Full text ]
Bieberich, E.;Tencomnao, T.;Kapitonov, D.;Yu, R.K. "Effect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells." Journal of neurochemistry 74, 6 (2000): 2359-64. [PubMed Link] | [ Full text ]
Bieberich, E. "Probing quantum coherence in a biological system by means of DNA amplification." Bio Systems 57, 2 (2000): 109-24. [PubMed Link] | [ Full text ]
Bieberich, E.;Kawaguchi, T.;Yu, R.K. "N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells." The Journal of biological chemistry 275, 1 (2000): 177-81. [PubMed Link] | [ Full text ]
Bieberich, E.;Kapitonov, D.;Tencomnao, T.;Yu, R.K. "Protein-ribosome-mRNA display: affinity isolation of enzyme-ribosome-mRNA complexes and cDNA cloning in a single-tube reaction." Analytical biochemistry 287, 2 (2000): 294-8. [PubMed Link] | [ Full text ]
Bieberich, E.;Liour, S.S.;Yu, R.K. "Mammalian ganglioside sialidases: preparation and activity assays." Methods in enzymology 312, (2000): 339-58. [PubMed Link] | [ Full text ]
Bieberich, E.;Freischütz, B.;Suzuki, M.;Yu, R.K. "Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells." Journal of neurochemistry 72, 3 (1999): 1040-9. [PubMed Link] | [ Full text ]
Bieberich, E.;Yu, R.K. "Multi-enzyme kinetic analysis of glycolipid biosynthesis." Biochimica et biophysica acta 1432, 1 (1999): 113-24. [PubMed Link] | [ Full text ]
Zeng, G.;Li, D.D.;Gao, L.;Birklé, S.;Bieberich, E.;Tokuda, A.;Yu, R.K. "Alteration of ganglioside composition by stable transfection with antisense vectors against GD3-synthase gene expression." Biochemistry 38, 27 (1999): 8762-9. [PubMed Link] | [ Full text ]
Kapitonov, D.;Bieberich, E.;Yu, R.K. "Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase." Glycoconjugate journal 16, 7 (1999): 337-50. [PubMed Link] |
Bieberich, E.;Freischütz, B.;Liour, S.S.;Yu, R.K. "Regulation of ganglioside metabolism by phosphorylation and dephosphorylation." Journal of neurochemistry 71, 3 (1998): 972-9. [PubMed Link] | [ Full text ]
Bieberich, E.;Treml, K.;Völker, C.;Rolfs, A.;Kalz-Füller, B.;Bause, E. "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells." European journal of biochemistry 246, 3 (1997): 681-9. [PubMed Link] | [ Full text ]
Bieberich, E.;Bause, E. "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein." European journal of biochemistry 233, 2 (1995): 644-9. [PubMed Link] | [ Full text ]
Kalz-Füller, B.;Bieberich, E.;Bause, E. "Cloning and expression of glucosidase I from human hippocampus." European journal of biochemistry 231, 2 (1995): 344-51. [PubMed Link] | [ Full text ]
Bause, E.;Bieberich, E.;Rolfs, A.;Völker, C.;Schmidt, B. "Molecular cloning and primary structure of Man9-mannosidase from human kidney." European journal of biochemistry 217, 2 (1993): 535-40. [PubMed Link] | [ Full text ]
Bieberich, E.;Legler, G. "Intracellular activity of lysosomal glucosylceramidase measured with 4-nonylumbelliferyl beta-glucoside." Biological chemistry Hoppe-Seyler 370, 8 (1989): 809-17. [PubMed Link] |
Legler, G.;Bieberich, E. "Active site directed inhibition of a cytosolic beta-glucosidase from calf liver by bromoconduritol B epoxide and bromoconduritol F." Archives of biochemistry and biophysics 260, 1 (1988): 437-42. [PubMed Link] | [ Full text ]
Legler, G.;Bieberich, E. "Isolation of a cytosolic beta-glucosidase from calf liver and characterization of its active site with alkyl glucosides and basic glycosyl derivatives." Archives of biochemistry and biophysics 260, 1 (1988): 427-36. [PubMed Link] | [ Full text ]
Bieberich, E. " The pediatric nurse in the social service ." Deutsche Krankenpflegezeitschrift 29, 11 (1976): 638-40. [PubMed Link] |