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Erhard Bieberich, PhD

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Erhard.Bieberich@uky.edu

(859) 323-8079

780 Rose Street, Medical Science Building, Rm: MS-519, Lexington, KY 40536-0298

Position(s):

Professor

Affiliation(s):

Physiology

Interests / Specialties:

Lipid biochemistry (focus ceramide

a sphingolipid)

Stem cell research and brain development

Neurodegeneration (focus Alzheimer's Disease)

Bio / Education:

1986: MS in Biochemistry, University of Cologne, Germany
1990: PhD in Biochemistry, University of Cologne, Germany
1990-1996: Post-doctoral fellow at the Department of Physiol. Chemistry, University of Bonn, Germany
1996-2000: Instructor and then Assistant Professor (1999) at the Department of Biochemistry, Virginia Commonwealth
University, Richmond, VA
2000-2017: Assistant, Associate (2004), and then full Professor (2011, tenured) at the Department of Neuroscience and
Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA
2017: Full Professor at the Department of Physiology, University of Kentucky, Lexington, GA

Research Description:

Our lab is interested in understanding the function of lipids, particularly the sphingolipid ceramide, in neural development and neurodegeneration. We have discovered that ceramide is enriched in membranes and compartments (ceramide-enriched compartments) that are critical for the function of primary and motile cilia in neural progenitor cells in brain development and exosomes in Alzheimer's disease. Current and future research is focused on understanding specific ceramide-protein interactions that regulate cell signaling in stem and neuroprogenitor cells, glial cells, and neurons.

Grants:

Currently, the lab is supported by 2 R01 and 1 NSF grants

PubMed Publications:

Zhu, Z.; Quadri, Z ; Crivelli, SM ; Elsherbini, A.; Zhang, L.; Tripathi, P.; Qin, H.; Roush, E ; Spassieva, SD ; Nikolova-Karakashian, M.; McClintock, TS ; Bieberich, E. "Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts." Molecular neurobiology 59, 5 (2022): 3233-3253. [PubMed Link] | [ Full text ]
Quadri, Z ; Elsherbini, A.; Bieberich, E. "Extracellular vesicles in pharmacology: Novel approaches in diagnostics and therapy." Pharmacological research 175, (2022): 105980. [PubMed Link] | [ Full text ]
Lewandowski, D ; Foik, AT ; Smidak, R ; Choi, EH ; Zhang, J.; Hoang, T.; Tworak, A ; Suh, S ; Leinonen, H ; Dong, Z.; Pinto, AF ; Tom, E ; Luu, J ; Lee, J.; Ma, X.; Bieberich, E.; Blackshaw, S.; Saghatelian, A ; Lyon, DC ; Skowronska-Krawczyk, D ; Tabaka, M ; Palczewski, K "Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision." JCI insight 7, 4 (2022): [PubMed Link] | [ Full text ]
Tripathi, P.; Shukla, P.; Bieberich, E. "Theranostic Applications of Nanomaterials in Alzheimer's Disease: A Multifunctional Approach." Current pharmaceutical design 28, 2 (2022): 116-132. [PubMed Link] | [ Full text ]
James, BN ; Oyeniran, C ; Sturgill, JL ; Newton, J ; Martin, RK ; Bieberich, E.; Weigel, C ; Maczis, MA ; Palladino, END ; Lownik, JC ; Trudeau, JB ; Cook-Mills, JM ; Wenzel, S ; Milstien, S ; Spiegel, S. "Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma." The Journal of allergy and clinical immunology 147, 5 (2021): 1936-1948.e9. [PubMed Link] | [ Full text ]
Crivelli, SM ; Luo, Q.; Stevens, JAA ; Giovagnoni, C ; van Kruining, D ; Bode, G ; Hoedt, den ; Hobo, B ; Scheithauer, AL ; Walter, J.; Mulder, MT ; Exley, C.; Mold, M ; Mielke, MM ; de Vries, HE ; Wouters, K ; van den Hove, DLA ; Berkes, D ; Ledesma, MD ; Verhaagen, J ; Losen, M ; Bieberich, E.; Martinez-Martinez, P "CERT<sub>L</sub> reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer's disease." Alzheimer's research & therapy 13, 1 (2021): 45. [PubMed Link] | [ Full text ]
Tripathi, P.; Zhu, Z.; Qin, H.; Elsherbini, A.; Roush, EA ; Crivelli, SM ; Spassieva, SD ; Bieberich, E. "Cross-Link/Proximity Ligation Assay for Visualization of Lipid and Protein Complexes in Lipid Rafts." Methods in molecular biology (Clifton, N.J.) 2187, (2021): 337-348. [PubMed Link] | [ Full text ]
Elsherbini, A.; Qin, H.; Zhu, Z.; Tripathi, P.; Wang, G.; Crivelli, SM ; Spassieva, SD ; Bieberich, E. "Extracellular Vesicles Containing Ceramide-Rich Platforms: "Mobile Raft" Isolation and Analysis." Methods in molecular biology (Clifton, N.J.) 2187, (2021): 87-98. [PubMed Link] | [ Full text ]
Tripathi, P.; Zhu, Z.; Qin, H.; Elsherbini, A.; Crivelli, SM ; Roush, E ; Wang, G.; Spassieva, SD ; Bieberich, E. "Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis." Journal of lipid research 62, (2021): 100021. [PubMed Link] | [ Full text ]
Becker, KA ; Uerschels, AK ; Goins, L ; Doolen, S.; McQuerry, KJ ; Bielawski, J.; Sure, U ; Bieberich, E.; Taylor, BK ; Gulbins, E ; Spassieva, SD "Role of 1-Deoxysphingolipids in docetaxel neurotoxicity." Journal of neurochemistry 154, 6 (2020): 662-672. [PubMed Link] | [ Full text ]
Crivelli, SM ; van Kruining, D ; Luo, Q.; Stevens, JAA ; Giovagnoni, C ; Paulus, A ; Bauwens, M ; Berkes, D ; de Vries, HE ; Mulder, MT ; Walter, J.; Waelkens, E ; Derua, R ; Swinnen, JV ; Dehairs, J ; Mottaghy, FM ; Losen, M ; Bieberich, E.; Martinez-Martinez, P "Ceramide analog <sup>18</sup>F F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer's disease transgenic mice by functioning as a metabolic probe." Scientific reports 10, 1 (2020): 19354. [PubMed Link] | [ Full text ]
Elsherbini, A.; Qin, H.; Zhu, Z.; Tripathi, P.; Crivelli, SM ; Bieberich, E. "In vivo evidence of exosome-mediated Aβ neurotoxicity." Acta neuropathologica communications 8, 1 (2020): 100. [PubMed Link] | [ Full text ]
Murakami, K.; Tenge, VR ; Karandikar, UC ; Lin, SC ; Ramani, S.; Ettayebi, K ; Crawford, SE ; Zeng, XL ; Neill, FH ; Ayyar, BV ; Katayama, K.; Graham, DY ; Bieberich, E.; Atmar, RL ; Estes, MK "Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids." Proceedings of the National Academy of Sciences of the United States of America 117, 3 (2020): 1700-1710. [PubMed Link] | [ Full text ]
Elsherbini, A.; Kirov, AS ; Dinkins, MB ; Wang, G.; Qin, H.; Zhu, Z.; Tripathi, P.; Crivelli, SM ; Bieberich, E. "Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity." Acta neuropathologica communications 8, 1 (2020): 60. [PubMed Link] | [ Full text ]
Crivelli, SM ; Giovagnoni, C ; Visseren, L ; Scheithauer, AL ; de Wit, N ; Hoedt, den ; Losen, M ; Mulder, MT ; Walter, J.; de Vries, HE ; Bieberich, E.; Martinez-Martinez, P "Sphingolipids in Alzheimer's disease, how can we target them?" Advanced drug delivery reviews 159, (2020): 214-231. [PubMed Link] | [ Full text ]
Zhu, Z.; Chen, J.; Wang, G.; Elsherbini, A.; Zhong, L.; Jiang, X.; Qin, H.; Tripathi, P.; Zhi, W.; Spassieva, SD ; Morris, AJ ; Bieberich, E. "Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes." Biochimica et biophysica acta. Molecular and cell biology of lipids 1864, 10 (2019): 1514-1524. [PubMed Link] | [ Full text ]
Zhong, L.; Jiang, X.; Zhu, Z.; Qin, H.; Dinkins, MB ; Kong, JN ; Leanhart, S.; Wang, R.; Elsherbini, A.; Bieberich, E.; Zhao, Y.; Wang, G. "Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide." Glia 67, 3 (2019): 498-511. [PubMed Link] | [ Full text ]
Nganga, R ; Oleinik, N ; Kim, J.; Selvam, SP ; De Palma, R ; Johnson, KA ; Parikh, RY ; Gangaraju, V ; Peterson, Y ; Dany, M ; Stahelin, RV ; Voelkel-Johnson, C.; Szulc, ZM ; Bieberich, E.; Ogretmen, B. "Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis." The Journal of biological chemistry 294, 2 (2019): 502-519. [PubMed Link] | [ Full text ]
Jiang, X.; Zhu, Z.; Qin, H.; Tripathi, P.; Zhong, L.; Elsherbini, A.; Karki, S.; Crivelli, SM ; Zhi, W.; Wang, G.; Spassieva, SD ; Bieberich, E. "Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody." Frontiers in cell and developmental biology 7, (2019): 166. [PubMed Link] | [ Full text ]
Bieberich, E. "Sphingolipids and lipid rafts: Novel concepts and methods of analysis." Chemistry and physics of lipids 216, (2018): 114-131. [PubMed Link] | [ Full text ]
Zhong, L.; Kong, JN ; Dinkins, MB ; Leanhart, S.; Zhu, Z.; Spassieva, SD ; Qin, H.; Lin, HP ; Elsherbini, A.; Wang, R.; Jiang, X.; Nikolova-Karakashian, M.; Wang, G.; Bieberich, E. "Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice." Journal of lipid research 59, 5 (2018): 795-804. [PubMed Link] | [ Full text ]
Kong, JN ; Zhu, Z.; Itokazu, Y.; Wang, G.; Dinkins, MB ; Zhong, L.; Lin, HP ; Elsherbini, A.; Leanhart, S.; Jiang, X.; Qin, H.; Zhi, W.; Spassieva, SD ; Bieberich, E. "Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes." Journal of lipid research 59, 3 (2018): 488-506. [PubMed Link] | [ Full text ]
Wang, G.; Bieberich, E. "Sphingolipids in neurodegeneration (with focus on ceramide and S1P)." Advances in biological regulation 70, (2018): 51-64. [PubMed Link] | [ Full text ]
Wang, G.; Spassieva, SD ; Bieberich, E. "Ceramide and S1P Signaling in Embryonic Stem Cell Differentiation." Methods in molecular biology (Clifton, N.J.) 1697, (2018): 153-171. [PubMed Link] | [ Full text ]
Elsherbini, A.; Bieberich, E. "Ceramide and Exosomes: A Novel Target in Cancer Biology and Therapy." Advances in cancer research 140, (2018): 121-154. [PubMed Link] | [ Full text ]
Burgert, A.; Schlegel, J.; Bécam, J.; Doose, S.; Bieberich, E.; Schubert-Unkmeir, A.; Sauer, M. "Characterization of Plasma Membrane Ceramides by Super-Resolution Microscopy." Angewandte Chemie (International ed. in English) 56, 22 (2017): 6131-6135. [PubMed Link] | [ Full text ]
Yue, HY ; Bieberich, E.; Xu, J. "Promotion of endocytosis efficiency through an ATP-independent mechanism at rat calyx of Held terminals." The Journal of physiology 595, 15 (2017): 5265-5284. [PubMed Link] | [ Full text ]
Helwa, I.; Cai, J.; Drewry, MD ; Zimmerman, A.; Dinkins, MB ; Khaled, ML ; Seremwe, M.; Dismuke, WM ; Bieberich, E.; Stamer, WD ; Hamrick, MW ; Liu, Y. "A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents." PloS one 12, 1 (2017): e0170628. [PubMed Link] | [ Full text ]
Dinkins, MB ; Wang, G.; Bieberich, E. "Sphingolipid-Enriched Extracellular Vesicles and Alzheimer's Disease: A Decade of Research." Journal of Alzheimer's disease : JAD 60, 3 (2017): 757-768. [PubMed Link] | [ Full text ]
Spassieva, S.; Bieberich, E. "Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease." Journal of neuroscience research 94, 11 (2016): 974-81. [PubMed Link] | [ Full text ]
Spassieva, SD ; Ji, X.; Liu, Y.; Gable, K.; Bielawski, J.; Dunn, TM ; Bieberich, E.; Zhao, L. "Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency." Proceedings of the National Academy of Sciences of the United States of America 113, 21 (2016): 5928-33. [PubMed Link] | [ Full text ]
Walter, T.; Collenburg, L.; Japtok, L.; Kleuser, B.; Schneider-Schaulies, S.; Müller, N.; Bécam, J.; Schubert-Unkmeir, A.; Kong, JN ; Bieberich, E.; Seibel, J. "Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells." Chemical communications (Cambridge, England) 52, 55 (2016): 8612-8614. [PubMed Link] | [ Full text ]
Dinkins, MB ; Enasko, J.; Hernandez, C.; Wang, G.; Kong, J.; Helwa, I.; Liu, Y.; Terry AV, Jr ; Bieberich, E. "Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse." The Journal of neuroscience : the official journal of the Society for Neuroscience 36, 33 (2016): 8653-67. [PubMed Link] | [ Full text ]
Kong, JN ; He, Q.; Wang, G.; Dasgupta, S.; Dinkins, MB ; Zhu, G.; Kim, A.; Spassieva, S.; Bieberich, E. "Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells." International journal of cancer 137, 7 (2015): 1610-20. [PubMed Link] | [ Full text ]
Kong, JN ; Hardin, K.; Dinkins, M.; Wang, G.; He, Q.; Mujadzic, T.; Zhu, G.; Bielawski, J.; Spassieva, S.; Bieberich, E. "Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3." Molecular biology of the cell 26, 24 (2015): 4451-65. [PubMed Link] | [ Full text ]
Dinkins, MB ; Dasgupta, S.; Wang, G.; Zhu, G.; He, Q.; Kong, JN ; Bieberich, E. "The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden." Journal of Alzheimer's disease : JAD 46, 1 (2015): 55-61. [PubMed Link] | [ Full text ]
He, Q.; Wang, G.; Wakade, S.; Dasgupta, S.; Dinkins, M.; Kong, JN ; Spassieva, SD ; Bieberich, E. "Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide." Molecular biology of the cell 25, 11 (2014): 1715-29. [PubMed Link] | [ Full text ]
Janes, K.; Little, JW ; Li, C.; Bryant, L.; Chen, C.; Chen, Z.; Kamocki, K.; Doyle, T.; Snider, A.; Esposito, E.; Cuzzocrea, S.; Bieberich, E.; Obeid, L.; Petrache, I.; Nicol, G.; Neumann, WL ; Salvemini, D. "The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1." The Journal of biological chemistry 289, 30 (2014): 21082-97. [PubMed Link] | [ Full text ]
Paschall, AV ; Zimmerman, MA ; Torres, CM ; Yang, D.; Chen, MR ; Li, X.; Bieberich, E.; Bai, A.; Bielawski, J.; Bielawska, A.; Liu, K. "Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression." BMC cancer 14, (2014): 24. [PubMed Link] | [ Full text ]
Bradley, E.; Zhao, X.; Wang, R.; Brann, D.; Bieberich, E.; Wang, G. "Low dose Hsp90 inhibitor 17AAG protects neural progenitor cells from ischemia induced death." Journal of cell communication and signaling 8, 4 (2014): 353-62. [PubMed Link] | [ Full text ]
Dinkins, MB ; Dasgupta, S.; Wang, G.; Zhu, G.; Bieberich, E. "Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease." Neurobiology of aging 35, 8 (2014): 1792-800. [PubMed Link] | [ Full text ]
Bradley, E.; Dasgupta, S.; Jiang, X.; Zhao, X.; Zhu, G.; He, Q.; Dinkins, M.; Bieberich, E.; Wang, G. "Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration." PloS one 9, 10 (2014): e110119. [PubMed Link] | [ Full text ]
Bieberich, E. "Synthesis, Processing, and Function of N-glycans in N-glycoproteins." Advances in neurobiology 9, (2014): 47-70. [PubMed Link] |
Dasgupta, S.; Kong, J.; Bieberich, E. "Phytoceramide in vertebrate tissues: one step chromatography separation for molecular characterization of ceramide species." PloS one 8, 11 (2013): e80841. [PubMed Link] | [ Full text ]
Bieberich, E. "Introduction to the fractality principle of consciousness and the sentyon postulate." Cognitive computation 4, 1 (2012): 13-28. [PubMed Link] |
Wang, G.; Dinkins, M.; He, Q.; Zhu, G.; Poirier, C.; Campbell, A.; Mayer-Proschel, M.; Bieberich, E. "Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD)." The Journal of biological chemistry 287, 25 (2012): 21384-95. [PubMed Link] | [ Full text ]
Bieberich, E. "It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation." Neurochemical research 37, 6 (2012): 1208-29. [PubMed Link] | [ Full text ]
He, Q.; Wang, G.; Dasgupta, S.; Dinkins, M.; Zhu, G.; Bieberich, E. "Characterization of an apical ceramide-enriched compartment regulating ciliogenesis." Molecular biology of the cell 23, 16 (2012): 3156-66. [PubMed Link] | [ Full text ]
Bradley, E.; Bieberich, E.; Mivechi, NF ; Tangpisuthipongsa, D.; Wang, G. "Regulation of embryonic stem cell pluripotency by heat shock protein 90." Stem cells (Dayton, Ohio) 30, 8 (2012): 1624-33. [PubMed Link] |
Bieberich, E. "Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation." Methods in molecular biology (Clifton, N.J.) 874, (2012): 177-92. [PubMed Link] | [ Full text ]
Bieberich, E. "There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells." Neurochemical research 36, 9 (2011): 1601-11. [PubMed Link] | [ Full text ]
Spassieva, S.; Bieberich, E. "The gut-to-breast connection - interdependence of sterols and sphingolipids in multidrug resistance and breast cancer therapy." Anti-cancer agents in medicinal chemistry 11, 9 (2011): 882-90. [PubMed Link] | [ Full text ]
Bieberich, E. "Lipid vesicle-mediated affinity chromatography using magnetic activated cell sorting (LIMACS): a novel method to analyze protein-lipid interaction." Journal of visualized experiments : JoVE 50 (2011): [PubMed Link] | [ Full text ]
Bieberich, E. "Ceramide in stem cell differentiation and embryo development: novel functions of a topological cell-signaling lipid and the concept of ceramide compartments." Journal of lipids 2011, (2011): 610306. [PubMed Link] | [ Full text ]
Muscoli, C.; Doyle, T.; Dagostino, C.; Bryant, L.; Chen, Z.; Watkins, LR ; Ryerse, J.; Bieberich, E.; Neumman, W.; Salvemini, D. "Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids." The Journal of neuroscience : the official journal of the Society for Neuroscience 30, 46 (2010): 15400-8. [PubMed Link] | [ Full text ]
Wang, G.; Bieberich, E. "Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development." Cell death & disease 1, (2010): e46. [PubMed Link] | [ Full text ]
Wang, G.; Krishnamurthy, K.; Bieberich, E. "Regulation of primary cilia formation by ceramide." Journal of lipid research 50, 10 (2009): 2103-10. [PubMed Link] | [ Full text ]
Wang, G.; Krishnamurthy, K.; Umapathy, NS ; Verin, AD ; Bieberich, E. "The carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells." The Journal of biological chemistry 284, 21 (2009): 14469-75. [PubMed Link] | [ Full text ]
Brooks, YS ; Wang, G.; Yang, Z.; Smith, KK ; Bieberich, E.; Ko, L. "Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation." The Journal of biological chemistry 284, 27 (2009): 18033-46. [PubMed Link] | [ Full text ]
Wang, G.; Silva, J.; Dasgupta, S.; Bieberich, E. "Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes." Glia 56, 4 (2008): 449-56. [PubMed Link] | [ Full text ]
Bieberich, E. "Ceramide signaling in cancer and stem cells." Future lipidology 3, 3 (2008): 273-300. [PubMed Link] |
Wang, G.; Krishnamurthy, K.; Chiang, YW ; Dasgupta, S.; Bieberich, E. "Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development." Journal of neurochemistry 106, 2 (2008): 718-33. [PubMed Link] | [ Full text ]
Ritter, E.; Perry, A.; Yu, J.; Wang, T.; Tang, L.; Bieberich, E. "Breast cancer cell-derived fibroblast growth factor 2 and vascular endothelial growth factor are chemoattractants for bone marrow stromal stem cells." Annals of surgery 247, 2 (2008): 310-4. [PubMed Link] | [ Full text ]
Krishnamurthy, K.; Wang, G.; Rokhfeld, D.; Bieberich, E. "Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide." Breast cancer research : BCR 10, 6 (2008): R106. [PubMed Link] | [ Full text ]
Bieberich, E. "Smart drugs for smarter stem cells: making SENSe (sphingolipid-enhanced neural stem cells) of ceramide." Neuro-Signals 16, 2-3 (2008): 124-39. [PubMed Link] | [ Full text ]
Krishnamurthy, K.; Wang, G.; Silva, J.; Condie, BG ; Bieberich, E. "Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis." The Journal of biological chemistry 282, 5 (2007): 3379-90. [PubMed Link] | [ Full text ]
Krishnamurthy, K.; Dasgupta, S.; Bieberich, E. "Development and characterization of a novel anti-ceramide antibody." Journal of lipid research 48, 4 (2007): 968-75. [PubMed Link] | [ Full text ]
Wang, G.; Silva, J.; Krishnamurthy, K.; Bieberich, E. "A novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells." Apoptosis : an international journal on programmed cell death 11, 3 (2006): 315-25. [PubMed Link] | [ Full text ]
Silva, J.; Dasgupta, S.; Wang, G.; Krishnamurthy, K.; Ritter, E.; Bieberich, E. "Lipids isolated from bone induce the migration of human breast cancer cells." Journal of lipid research 47, 4 (2006): 724-33. [PubMed Link] | [ Full text ]
Bieberich, E. "Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells." Analytical biochemistry 346, 1 (2005): 185-7. [PubMed Link] | [ Full text ]
Wang, G.; Silva, J.; Krishnamurthy, K.; Tran, E.; Condie, BG ; Bieberich, E. "Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells." The Journal of biological chemistry 280, 28 (2005): 26415-24. [PubMed Link] | [ Full text ]
Bieberich, E.; Silva, J.; Wang, G.; Krishnamurthy, K.; Condie, BG "Selective apoptosis of pluripotent mouse and human stem cells by novel ceramide analogues prevents teratoma formation and enriches for neural precursors in ES cell-derived neural transplants." The Journal of cell biology 167, 4 (2004): 723-34. [PubMed Link] | [ Full text ]
Yu, RK ; Bieberich, E.; Xia, T.; Zeng, G. "Regulation of ganglioside biosynthesis in the nervous system." Journal of lipid research 45, 5 (2004): 783-93. [PubMed Link] | [ Full text ]
Bieberich, E.; Anthony, GE "Neuronal differentiation and synapse formation of PC12 and embryonic stem cells on interdigitated microelectrode arrays: contact structures for neuron-to-electrode signal transmission (NEST)." Biosensors & bioelectronics 19, 8 (2004): 923-31. [PubMed Link] | [ Full text ]
Slaughter, GE ; Bieberich, E.; Wnek, GE ; Wynne, KJ ; Guiseppi-Elie, A. "Improving neuron-to-electrode surface attachment via alkanethiol self-assembly: an alternating current impedance study." Langmuir : the ACS journal of surfaces and colloids 20, 17 (2004): 7189-200. [PubMed Link] | [ Full text ]
Bieberich, E. "Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis." Glycoconjugate journal 21, 6 (2004): 315-27. [PubMed Link] |
Tencomnao, T.; Kapitonov, D.; Bieberich, E.; Yu, RK "Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE." Glycoconjugate journal 20, 5 (2004): 339-51. [PubMed Link] |
Silva, J.; Beckedorf, A.; Bieberich, E. "Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells." The Journal of biological chemistry 278, 28 (2003): 25376-85. [PubMed Link] | [ Full text ]
Bieberich, E.; MacKinnon, S.; Silva, J.; Noggle, S.; Condie, BG "Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide." The Journal of cell biology 162, 3 (2003): 469-79. [PubMed Link] | [ Full text ]
Bieberich, E.; MacKinnon, S.; Silva, J.; Li, DD ; Tencomnao, T.; Irwin, L.; Kapitonov, D.; Yu, RK "Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases." Biochemistry 41, 38 (2002): 11479-87. [PubMed Link] | [ Full text ]
Bieberich, E.; Hu, B.; Silva, J.; MacKinnon, S.; Yu, RK ; Fillmore, H.; Broaddus, WC ; Ottenbrite, RM "Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells." Cancer letters 181, 1 (2002): 55-64. [PubMed Link] | [ Full text ]
Bieberich, E. "Recurrent fractal neural networks: a strategy for the exchange of local and global information processing in the brain." Bio Systems 66, 3 (2002): 145-64. [PubMed Link] | [ Full text ]
Bieberich, E.; MacKinnon, S.; Silva, J.; Yu, RK "Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides." The Journal of biological chemistry 276, 48 (2001): 44396-404. [PubMed Link] | [ Full text ]
Yu, RK ; Bieberich, E. "Regulation of glycosyltransferases in ganglioside biosynthesis by phosphorylation and dephosphorylation." Molecular and cellular endocrinology 177, 1-2 (2001): 19-24. [PubMed Link] | [ Full text ]
Liour, SS ; Jones, MZ ; Suzuki, M.; Bieberich, E.; Yu, RK "Metabolic studies of glycosphingolipid accumulation in mucopolysaccharidosis IIID." Molecular genetics and metabolism 72, 3 (2001): 239-47. [PubMed Link] | [ Full text ]
Ren, S.; Kambe, N.; Du, Z.; Li, Y.; Xia, HZ ; Kambe, M.; Bieberich, E.; Pozez, A.; Grimes, M.; Yu, RK ; Irani, AM ; Schwartz, LB "Disialoganglioside GD3 is selectively expressed by developing and mature human mast cells." The Journal of allergy and clinical immunology 107, 2 (2001): 322-30. [PubMed Link] | [ Full text ]
Bieberich, E.; Tencomnao, T.; Kapitonov, D.; Yu, RK "Effect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells." Journal of neurochemistry 74, 6 (2000): 2359-64. [PubMed Link] | [ Full text ]
Bieberich, E. "Probing quantum coherence in a biological system by means of DNA amplification." Bio Systems 57, 2 (2000): 109-24. [PubMed Link] | [ Full text ]
Bieberich, E.; Kawaguchi, T.; Yu, RK "N-acylated serinol is a novel ceramide mimic inducing apoptosis in neuroblastoma cells." The Journal of biological chemistry 275, 1 (2000): 177-81. [PubMed Link] | [ Full text ]
Bieberich, E.; Kapitonov, D.; Tencomnao, T.; Yu, RK "Protein-ribosome-mRNA display: affinity isolation of enzyme-ribosome-mRNA complexes and cDNA cloning in a single-tube reaction." Analytical biochemistry 287, 2 (2000): 294-8. [PubMed Link] | [ Full text ]
Bieberich, E.; Liour, SS ; Yu, RK "Mammalian ganglioside sialidases: preparation and activity assays." Methods in enzymology 312, (2000): 339-58. [PubMed Link] | [ Full text ]
Bieberich, E.; Freischütz, B.; Suzuki, M.; Yu, RK "Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells." Journal of neurochemistry 72, 3 (1999): 1040-9. [PubMed Link] | [ Full text ]
Bieberich, E.; Yu, RK "Multi-enzyme kinetic analysis of glycolipid biosynthesis." Biochimica et biophysica acta 1432, 1 (1999): 113-24. [PubMed Link] | [ Full text ]
Zeng, G.; Li, DD ; Gao, L.; Birklé, S.; Bieberich, E.; Tokuda, A.; Yu, RK "Alteration of ganglioside composition by stable transfection with antisense vectors against GD3-synthase gene expression." Biochemistry 38, 27 (1999): 8762-9. [PubMed Link] | [ Full text ]
Kapitonov, D.; Bieberich, E.; Yu, RK "Combinatorial PCR approach to homology-based cloning: cloning and expression of mouse and human GM3-synthase." Glycoconjugate journal 16, 7 (1999): 337-50. [PubMed Link] |
Bieberich, E.; Freischütz, B.; Liour, SS ; Yu, RK "Regulation of ganglioside metabolism by phosphorylation and dephosphorylation." Journal of neurochemistry 71, 3 (1998): 972-9. [PubMed Link] | [ Full text ]
Bieberich, E.; Treml, K.; Völker, C.; Rolfs, A.; Kalz-Füller, B.; Bause, E. "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells." European journal of biochemistry 246, 3 (1997): 681-9. [PubMed Link] | [ Full text ]
Bieberich, E.; Bause, E. "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein." European journal of biochemistry 233, 2 (1995): 644-9. [PubMed Link] | [ Full text ]
Kalz-Füller, B.; Bieberich, E.; Bause, E. "Cloning and expression of glucosidase I from human hippocampus." European journal of biochemistry 231, 2 (1995): 344-51. [PubMed Link] | [ Full text ]
Bause, E.; Bieberich, E.; Rolfs, A.; Völker, C.; Schmidt, B. "Molecular cloning and primary structure of Man9-mannosidase from human kidney." European journal of biochemistry 217, 2 (1993): 535-40. [PubMed Link] | [ Full text ]
Bieberich, E.; Legler, G. "Intracellular activity of lysosomal glucosylceramidase measured with 4-nonylumbelliferyl beta-glucoside." Biological chemistry Hoppe-Seyler 370, 8 (1989): 809-17. [PubMed Link] |
Legler, G.; Bieberich, E. "Active site directed inhibition of a cytosolic beta-glucosidase from calf liver by bromoconduritol B epoxide and bromoconduritol F." Archives of biochemistry and biophysics 260, 1 (1988): 437-42. [PubMed Link] | [ Full text ]
Legler, G.; Bieberich, E. "Isolation of a cytosolic beta-glucosidase from calf liver and characterization of its active site with alkyl glucosides and basic glycosyl derivatives." Archives of biochemistry and biophysics 260, 1 (1988): 427-36. [PubMed Link] | [ Full text ]
Bieberich, E. " The pediatric nurse in the social service ." Deutsche Krankenpflegezeitschrift 29, 11 (1976): 638-40. [PubMed Link] |