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- paco.andrade@uky.edu
- (859) 323-6576
- 800 Rose Street, Medical Science Building, Rm: MS-511, (Lab) MS-539
- Lexington, KY 40536-0298
- @ricercar01
Ph.D. (Physiology) University of Texas Health Science Center at San Antonio, San Antonio, Texas, 1994.
Skeletal muscle is a very plastic tissue. Everybody is familiar with muscle's response to exercise: shifts in activity patterns activate molecular pathways that induce predictable changes in muscle size and metabolic properties. However, some muscles and motor systems deviate from these stereotypical changes. These variants of the skeletal muscle “mold” also react differently to neuromuscular diseases, mitochondrial myopathies, and some muscular dystrophies. My laboratory studies respiratory, extraocular and other craniofacial muscles, all constantly active motor systems that also have peculiar phenotypes. Our experimental approach uses multiple animal models and techniques to analyze how these muscles and their corresponding motor neurons communicate, and how their gene expression, metabolism and contractile function change in response to activity, stressors, and age.
Gamboa, J.L., Andrade, F.H. Mitochondrial content and distribution changes specific to mouse diaphragm after chronic normobaric hypoxia. Am. J. Physiol., Regul. Integr. Comp. Physiol., 298:R575-83, 2010.
Fry, L.T., Stemple, J.C., Andreatta, R.D., Harrison, A.L., Andrade, F.H. Effect of dystrophin deficiency on selected intrinsic laryngeal muscles of the mdx mouse. J. Speech Lang. Hear. Res., 53:633-47, 2010.
McMullen, C.A., Andrade, F.H., Crish, S.D. Underdeveloped extraocular muscles in the naked mole-rat (Heterocephalus glaber). Anat. Rec., 293:918-23, 2010.
Moncman, C.L., Andrade, F.H. Nonmuscle myosin IIB, a sarcomeric component in the extraocular muscles. Exp. Cell Res., 316:1958-65, 2010.
Garcia-Cazarin, M.L., Fisher, T.M., Andrade, F.H. Insulin and contractile activity regulate glucose uptake in rat extraocular muscles. Invest. Ophthalmol. Vis. Sci., 51:6364-8, 2010.
Gamboa, J.L., Garcia-Cazarin, M.L., Andrade, F.H. Chronic hypoxia increases insulin-stimulated glucose uptake in mouse skeletal muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol., 300:R85-91, 2011.
Moncman, C.L., Andrade, M.E., Andrade, F.H. Postnatal changes in the developing rat extraocular muscles. Invest. Ophthalmol. Vis. Sci., 52:3962-9, 2011.
Garcia-Cazarin, M.L., Gamboa, J.L., Andrade, F.H. Diaphragm mitochondria have lower intrinsic respiratory rates than mitochondria in limb muscles. Am. J. Physiol. Regul. Integr. Comp. Physiol., 300:R1311-5, 2011.
Garcia-Cazarin, M.L., Snider, N.N., Andrade, F.H. Mitochondrial isolation from skeletal muscle. J. Vis. Exp., doi: 10.3791/2452, 2011.
Gamboa, J.L., Andrade, F.H. Muscle endurance and mitochondrial function after chronic normobaric hypoxia: contrast of respiratory and limb muscles. Pflügers Arch. 463:327-338, 2012.
Carter, L.G., Lewis, K.N., Wilkerson, D.C., Tobia, C.M., Ngo Tenlep, S.Y., Shridas, P., Garcia-Cazarin, M.L., Wolff, G., Andrade, F.H., Charnigo, R.J., Esser, K.A., Egan, J.M., de Cabo, R., Pearson, K.J. Perinatal exercise improves glucose homeostasis in adult offspring. Am. J. Physiol. Endocrinol. Metab. 303:E1061-E1068, 2012.