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Lance A. Johnson, PhD
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Johnson.Lance@uky.edu
(859) 323-2746
800 Rose Street, Medical Science Building, Rm: MS-609, Lexington, KY 40536-0298
www.LJohnsonLab.com
Position(s): 
Assistant Professor, Department of Physiology
Affiliation(s): 
Physiology
Sanders-Brown Center on Aging/Alzheimer’s Disease Research Center
Office of Biomedical Education
Other Affiliation(s): 
Nutritional Sciences Graduate Faculty
TRAC Committee
Interests / Specialties: 
Apolipoprotein E
metabolic disease
Aging
Vascular Disease
Alzheimer's disease
Bio / Education: 

Postdoctoral, Behavioral Neuroscience, Oregon Health & Science University, 2011-16
PhD, Molecular & Cellular Pathology, University of North Carolina, 2011
BA, Journalism & Mass Communication, University of North Carolina, 2003

Research Description: 

Research in our lab is devoted to exploring the metabolic effects of the E4 isoform of apolipoprotein E (apoE), a major genetic risk factor for both cardiovascular disease and Alzheimer's disease. In particular, we focus on the role of apoE in the background of a critical - and increasingly common - environmental risk factor: diet-induced obesity and insulin resistance. Together, our studies tackle a critical question: are the cognitive and cerebrovascular impairments associated with E4 metabolic in nature?
In an attempt to answer this question, our research efforts lie at the intersection of vascular biology, metabolism, and neuroscience. Our studies revolve around two main areas: 1) the role of APOE genotype in regulating metabolism and driving vascular disease, and 2) the cerebrovascular and neurological effects of obesity and insulin resistance. Our goal is to identify novel nutritional and therapeutic targets, and to translate these findings into new approaches to prevent debilitating vascular and neurodegenerative disorders.

PubMed Publications: 
  • Johnson, LA ; Torres, ER ; Weber Boutros, S.; Patel, E.; Akinyeke, T.; Alkayed, NJ ; Raber, J. "Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 39, 5 (2019): 770-781. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Zuloaga, DG ; Bidiman, E.; Marzulla, T.; Weber, S.; Wahbeh, H.; Raber, J. "Correction: ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 44, 3 (2019): 654. [PubMed Link] |
  • Miranda, CL ; Johnson, LA ; Montgolfier, O.; Elias, VD ; Ullrich, LS ; Hay, JJ ; Paraiso, IL ; Choi, J.; Reed, RL ; Revel, JS ; Kioussi, C.; Bobe, G.; Iwaniec, UT ; Turner, RT ; Katzenellenbogen, BS ; Katzenellenbogen, JA ; Blakemore, PR ; Gombart, AF ; Maier, CS ; Raber, J.; Stevens, JF "Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice." Scientific reports 8, 1 (2018): 613. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Torres, ER ; Impey, S.; Stevens, JF ; Raber, J. "Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome." Scientific reports 7, (2017): 43701. [PubMed Link] | [ Full text ]
  • Arbones-Mainar, JM ; Johnson, LA ; Torres-Perez, E.; Garcia, AE ; Perez-Diaz, S.; Raber, J.; Maeda, N. "Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4." International journal of obesity (2005) 40, 10 (2016): 1574-1581. [PubMed Link] | [ Full text ]
  • Zuloaga, KL ; Johnson, LA ; Roese, NE ; Marzulla, T.; Zhang, W.; Nie, X.; Alkayed, FN ; Hong, C.; Grafe, MR ; Pike, MM ; Raber, J.; Alkayed, NJ "High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 36, 7 (2016): 1257-70. [PubMed Link] |
  • Johnson, LA ; Zuloaga, KL ; Kugelman, TL ; Mader, KS ; Morré, JT ; Zuloaga, DG ; Weber, S.; Marzulla, T.; Mulford, A.; Button, D.; Lindner, JR ; Alkayed, NJ ; Stevens, JF ; Raber, J. "Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma." EBioMedicine 3, (2016): 26-42. [PubMed Link] | [ Full text ]
  • Zuloaga, DG ; Johnson, LA ; Weber, S.; Raber, J. "Immediate and lasting effects of chronic daily methamphetamine exposure on activation of cells in hypothalamic-pituitary-adrenal axis-associated brain regions." Psychopharmacology 233, 3 (2016): 381-92. [PubMed Link] | [ Full text ]
  • Stevens, JF ; Johnson, L.; Miranda, CL ; Elias, VD ; Hay, JJ ; Raber, J. "Xanthohumol and its derivatives mitigate metabolic syndrome and associated cognitive impairments in obese C57BL/6J mice." Planta medica 81, S 01 (2016): S1-S381. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Zuloaga, DG ; Bidiman, E.; Marzulla, T.; Weber, S.; Wahbeh, H.; Raber, J. "ApoE2 Exaggerates PTSD-Related Behavioral, Cognitive, and Neuroendocrine Alterations." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 40, 10 (2015): 2443-53. [PubMed Link] |
  • Zuloaga, DG ; Johnson, LA ; Agam, M.; Raber, J. "Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine." Journal of neurochemistry 129, 3 (2014): 495-508. [PubMed Link] |
  • Perez-Diaz, S.; Johnson, LA ; DeKroon, RM ; Moreno-Navarrete, JM ; Alzate, O.; Fernandez-Real, JM ; Maeda, N.; Arbones-Mainar, JM "Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, 8 (2014): 3769-79. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Olsen, RH ; Merkens, LS ; DeBarber, A.; Steiner, RD ; Sullivan, PM ; Maeda, N.; Raber, J. "Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner." Neurobiology of disease 64, (2014): 150-62. [PubMed Link] | [ Full text ]
  • Haley, GE ; Yeiser, L.; Olsen, RH ; Davis, MJ ; Johnson, LA ; Raber, J. "Early effects of whole-body (56)Fe irradiation on hippocampal function in C57BL/6J mice." Radiation research 179, 5 (2013): 590-6. [PubMed Link] |
  • Johnson, LA ; Kim, HS ; Knudson, MJ ; Nipp, CT ; Yi, X.; Maeda, N. "Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation." Journal of lipid research 54, 2 (2013): 386-96. [PubMed Link] | [ Full text ]
  • Olsen, RH ; Johnson, LA ; Zuloaga, DG ; Limoli, CL ; Raber, J. "Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria." Journal of neurochemistry 125, 2 (2013): 303-13. [PubMed Link] |
  • Pendse, AA ; Johnson, LA ; Kim, HS ; McNair, M.; Nipp, CT ; Wilhelm, C.; Maeda, N. "Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice." Arteriosclerosis, thrombosis, and vascular biology 32, 6 (2012): 1436-44. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Arbones-Mainar, JM ; Fox, RG ; Pendse, AA ; Altenburg, MK ; Kim, HS ; Maeda, N. "Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor." Diabetes 60, 9 (2011): 2285-94. [PubMed Link] | [ Full text ]
  • Arbones-Mainar, JM ; Johnson, LA ; Altenburg, MK ; Kim, HS ; Maeda, N. "Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 10 (2010): 3809-18. [PubMed Link] | [ Full text ]
  • Pendse, AA ; Johnson, LA ; Tsai, YS ; Maeda, N. "Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction." Diabetes 59, 11 (2010): 2890-7. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Maeda, N. "Macrovascular complications of diabetes in atherosclerosisprone mice." Expert review of endocrinology & metabolism 5, 1 (2010): 89-98. [PubMed Link] |
  • Pendse, AA ; Arbones-Mainar, JM ; Johnson, LA ; Altenburg, MK ; Maeda, N. "Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond." Journal of lipid research 50 Suppl, (2009): S178-82. [PubMed Link] | [ Full text ]
  • Arbones-Mainar, JM ; Johnson, LA ; Altenburg, MK ; Maeda, N. "Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice." International journal of obesity (2005) 32, 10 (2008): 1595-605. [PubMed Link] | [ Full text ]
  • Johnson, LA ; Altenburg, MK ; Walzem, RL ; Scanga, LT ; Maeda, N. "Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences." Arteriosclerosis, thrombosis, and vascular biology 28, 10 (2008): 1745-52. [PubMed Link] | [ Full text ]
  • Altenburg, M.; Arbones-Mainar, J.; Johnson, L.; Wilder, J.; Maeda, N. "Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice." Arteriosclerosis, thrombosis, and vascular biology 28, 6 (2008): 1104-10. [PubMed Link] |
  • Maeda, N.; Johnson, L.; Kim, S.; Hagaman, J.; Friedman, M.; Reddick, R. "Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgrounds." Atherosclerosis 195, 1 (2007): 75-82. [PubMed Link] | [ Full text ]
  • Altenburg, M.; Johnson, L.; Wilder, J.; Maeda, N. "Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner." The Journal of biological chemistry 282, 11 (2007): 7817-24. [PubMed Link] | [ Full text ]
800 Rose Street, MS508
Lexington, KY 40536
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