Research in our lab is devoted to exploring the metabolic effects of the E4 isoform of apolipoprotein E (apoE), a major genetic risk factor for both cardiovascular disease and Alzheimer's disease. In particular, we focus on the role of apoE in the background of a critical - and increasingly common - environmental risk factor: diet-induced obesity and insulin resistance. Together, our studies tackle a critical question: are the cognitive and cerebrovascular impairments associated with E4 metabolic in nature?
In an attempt to answer this question, our research efforts lie at the intersection of vascular biology, metabolism, and neuroscience. Our studies revolve around two main areas: 1) the role of APOE genotype in regulating metabolism and driving vascular disease, and 2) the cerebrovascular and neurological effects of obesity and insulin resistance. Our goal is to identify novel nutritional and therapeutic targets, and to translate these findings into new approaches to prevent debilitating vascular and neurodegenerative disorders.