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Samirkumar Pravinbhai Patel, Ph.D.
skpate2's picture
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skpate2@uky.edu
(859) 323-6477
741 South Limestone Street, Biomedical & Biological Science Research Building, Rm: B461, Lexington, KY 40536-0509
PDF icon Samir Patel CV.pdf
Position(s): 
Research Assistant Professor
Spinal Cord & Brain Injury Research Center (SCoBIRC), Department of Physiology
Affiliation(s): 
Spinal Cord and Brain Injury Research Center
Physiology
Other Affiliation(s): 
SCOBIRC - Research Faculty
Grants: 

Current Research Funding:

1) Mitochondrial transplantation combined with mitochondrial-targeted pharmaceuticals to treat spinal cord injury.

Principle Investigator: A.G. Rabchevsky (06/01/20 - 05/31/23)

Co-Investigators: S.P. Patel., P.G. Sullivan, T. Dziubla, J. DeRouchey
Agency: Department of Defense (CDMRP/SCIRP) SC190110

Type: Investigator-Initiated Research Award

The proposed experiments are designed to test the protective efficacy of mitochondrial transplantation alone or in combination with neuroprotective agents for long-term functional recovery following contusion SCI. We will 1) establish that transplantation of isolated mitochondria be delivered through diffusible hydrogel polymers subdurally into spinal cords, 2) test the hypothesis that mitochondrial transplantation in combination with mitochondrial -targeted pharmaceuticals will ameliorate acute and sub-acute biochemical and cellular outcome measures compared to individual therapies , and test the hypothesis that combinatorial regimens will maximize long-term functional neuroprotection.

2) Chronic muscle weakness in sepsis survivors.
Principle Investigator: H. Saito (09/01/17 - 10/31/22)
Co-Investigators: S.P. Patel
Agency: NIH-NINDS
Type: R01
These studies will establish mitochondrial damage and dysfunction in sepsis-surviving mice, investigate sarcomeric protein damage and its causal mechanisms long after recovery from sepsis, and formulate therapeutic strategies to ameliorate post-sepsis chronic muscle weakness.

3) Pioglitazone fosters neuroprotection via specific interaction with mitoNEET
Principle Investigator: A.G. Rabchevsky (07/01/17 – 06/30/21) NCE
Co-Investigators: S.P. Patel, P.G. Sullivan and J.C. Gensel
Agency: The Craig H. Neilsen Foundation - Senior Research Grant
Type: Senior Investigator Grant
These studies will directly test whether pioglitazone affords neuroprotection following SCI by directly ameliorating mitochondrial dysfunction via interactions with mitoNEET using a novel transgenic model (mitoNEET null), as well as a novel specific mitoNEET ligand and an antagonist, alone and in tandem, to mechanistically test our hypotheses.

PubMed Publications: 
  • Stewart, AN ; McFarlane, KE ; Vekaria, HJ ; Bailey, WM ; Slone, SA ; Tranthem, LA ; Zhang, B.; Patel, SP ; Sullivan, PG ; Gensel, JC "Mitochondria exert age-divergent effects on recovery from spinal cord injury." Experimental neurology 337, (2021): 113597. [PubMed Link] | [ Full text ]
  • Eldahan, KC ; Williams, HC ; Cox, DH ; Gollihue, JL ; Patel, SP ; Rabchevsky, AG "Paradoxical effects of continuous high dose gabapentin treatment on autonomic dysreflexia after complete spinal cord injury." Experimental neurology 323, (2020): 113083. [PubMed Link] | [ Full text ]
  • Rabchevsky, AG ; Michael, FM ; Patel, SP "Mitochondria focused neurotherapeutics for spinal cord injury." Experimental neurology 330, (2020): 113332. [PubMed Link] |
  • Owen, AM ; Patel, SP ; Smith, JD ; Balasuriya, BK ; Mori, SF ; Hawk, GS ; Stromberg, AJ ; Kuriyama, N ; Kaneki, M.; Rabchevsky, AG ; Butterfield, TA ; Esser, KA ; Peterson, CA ; Starr, ME ; Saito, H. "Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model." eLife 8, (2019): [PubMed Link] |
  • Michael, FM ; Patel, SP ; Rabchevsky, AG "Intraspinal Plasticity Associated With the Development of Autonomic Dysreflexia After Complete Spinal Cord Injury." Frontiers in cellular neuroscience 13, (2019): 505. [PubMed Link] | [ Full text ]
  • Eldahan, KC ; Cox, DH ; Gollihue, JL ; Patel, SP ; Rabchevsky, AG "Rapamycin Exacerbates Cardiovascular Dysfunction after Complete High-Thoracic Spinal Cord Injury." Journal of neurotrauma 35, 6 (2018): 842-853. [PubMed Link] | [ Full text ]
  • Gollihue, JL ; Patel, SP ; Rabchevsky, AG "Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma." Neural regeneration research 13, 2 (2018): 194-197. [PubMed Link] | [ Full text ]
  • Gollihue, JL ; Patel, SP ; Eldahan, KC ; Cox, DH ; Donahue, RR ; Taylor, BK ; Sullivan, PG ; Rabchevsky, AG "Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury." Journal of neurotrauma 35, 15 (2018): 1800-1818. [PubMed Link] | [ Full text ]
  • Rabchevsky, AG ; Patel, SP ; Sullivan, PG "Targeting mitoNEET with pioglitazone for therapeutic neuroprotection after spinal cord injury." Neural regeneration research 12, 11 (2017): 1807-1808. [PubMed Link] | [ Full text ]
  • Patel, SP ; Cox, DH ; Gollihue, JL ; Bailey, WM ; Geldenhuys, WJ ; Gensel, JC ; Sullivan, PG ; Rabchevsky, AG "Pioglitazone treatment following spinal cord injury maintains acute mitochondrial integrity and increases chronic tissue sparing and functional recovery." Experimental neurology 293, (2017): 74-82. [PubMed Link] |
  • Gollihue, JL ; Patel, SP ; Mashburn, C.; Eldahan, KC ; Sullivan, PG ; Rabchevsky, AG "Optimization of mitochondrial isolation techniques for intraspinal transplantation procedures." Journal of neuroscience methods 287, (2017): 1-12. [PubMed Link] | [ Full text ]
  • Patel, SP ; Smith, TD ; VanRooyen, JL ; Powell, D.; Cox, DH ; Sullivan, PG ; Rabchevsky, AG "Serial Diffusion Tensor Imaging In Vivo Predicts Long-Term Functional Recovery and Histopathology in Rats following Different Severities of Spinal Cord Injury." Journal of neurotrauma 33, 10 (2016): 917-28. [PubMed Link] |
  • Visavadiya, NP ; Patel, SP ; VanRooyen, JL ; Sullivan, PG ; Rabchevsky, AG "Cellular and subcellular oxidative stress parameters following severe spinal cord injury." Redox biology 8, (2016): 59-67. [PubMed Link] | [ Full text ]
  • Patel, SP ; Sullivan, PG ; Pandya, JD ; Goldstein, GA ; VanRooyen, JL ; Yonutas, HM ; Eldahan, KC ; Morehouse, J.; Magnuson, DS ; Rabchevsky, AG "N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma." Experimental neurology 257, (2014): 95-105. [PubMed Link] | [ Full text ]
  • Pandya, JD ; Readnower, RD ; Patel, SP ; Yonutas, HM ; Pauly, JR ; Goldstein, GA ; Rabchevsky, AG ; Sullivan, PG "N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI." Experimental neurology 257, (2014): 106-13. [PubMed Link] | [ Full text ]
  • Zhang, X.; Patel, SP ; McCarthy, JJ ; Rabchevsky, AG ; Goldhamer, DJ ; Esser, KA "A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle." Nucleic acids research 40, 8 (2012): 3419-30. [PubMed Link] | [ Full text ]
  • Rabchevsky, AG ; Patel, SP ; Lyttle, TS ; Eldahan, KC ; O'Dell, CR ; Zhang, Y.; Popovich, PG ; Kitzman, PH ; Donohue, KD "Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury." Frontiers in physiology 3, (2012): 329. [PubMed Link] | [ Full text ]
  • Rabchevsky, AG ; Patel, SP ; Springer, JE "Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward?" Pharmacology & therapeutics 132, 1 (2011): 15-29. [PubMed Link] | [ Full text ]
  • Patel, SP ; Sullivan, PG ; Lyttle, TS ; Rabchevsky, AG "Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury." Journal of neurochemistry 114, 1 (2010): 291-301. [PubMed Link] | [ Full text ]
  • Laudanski, K.; Patel, SP ; Peng, YG "Ongoing paradoxical particulate embolism during megaprosthesis placement." Journal of clinical anesthesia 21, 7 (2009): 533-7. [PubMed Link] | [ Full text ]
  • Patel, SP ; Gamboa, JL ; McMullen, CA ; Rabchevsky, A.; Andrade, FH "Lower respiratory capacity in extraocular muscle mitochondria: evidence for intrinsic differences in mitochondrial composition and function." Investigative ophthalmology & visual science 50, 1 (2009): 180-6. [PubMed Link] | [ Full text ]
  • Patel, SP ; Sullivan, PG ; Pandya, JD ; Rabchevsky, AG "Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury." Journal of neuroscience research 87, 1 (2009): 130-140. [PubMed Link] |
  • Katyare, SS ; Patel, SP ; Modi, HR "Diabetic modulation of the temperature kinetics properties of cytochrome oxidase activity in rat brain mitochondria." Neurochemical research 33, 3 (2008): 422-9. [PubMed Link] | [ Full text ]
  • Modi, HR ; Katyare, SS ; Patel, SP "Thyroidal regulation of substrate kinetics properties of cytochrome oxidase in rat liver mitochondria." Indian journal of clinical biochemistry : IJCB 23, 3 (2008): 272-8. [PubMed Link] |
  • Katyare, SS ; Modi, HR ; Patel, SP ; Patel, MA "Thyroid hormone-induced alterations in membrane structure-function relationships: studies on kinetic properties of rat kidney microsomal Na(+),K (+)-ATPase and lipid/phospholipid profiles." The Journal of membrane biology 219, 1-3 (2007): 71-81. [PubMed Link] | [ Full text ]
  • Akhileshwar, V.; Patel, SP ; Katyare, SS "Diabetic cardiomyopathy and reactive oxygen species (ROS) related parameters in male and female rats: A comparative study." Indian journal of clinical biochemistry : IJCB 22, 1 (2007): 84-90. [PubMed Link] |
  • Sullivan, PG ; Krishnamurthy, S.; Patel, SP ; Pandya, JD ; Rabchevsky, AG "Temporal characterization of mitochondrial bioenergetics after spinal cord injury." Journal of neurotrauma 24, 6 (2007): 991-9. [PubMed Link] | [ Full text ]
  • Modi, HR ; Patel, SP ; Katyare, SS ; Patel, M. "Thyroid hormone treatments differentially affect the temperature kinetics properties of FoF1 ATPase and succinate oxidase as well as the lipid/phospholipid profiles of rat kidney mitochondria: a correlative study." The Journal of membrane biology 215, 2-3 (2007): 135-45. [PubMed Link] | [ Full text ]
  • Patel, SP ; Patel, MA ; Modi, HR ; Katyare, SS "Improved method for estimation of inorganic phosphate: implications for its application in enzyme assays." Indian journal of biochemistry & biophysics 44, 2 (2007): 88-93. [PubMed Link] |
  • Patel, SP ; Katyare, SS "Effect of alloxan-diabetes and subsequent treatment with insulin on kinetic properties of succinate oxidase activity from rat liver mitochondria." Zeitschrift fur Naturforschung. C, Journal of biosciences 61, 9-10 (2006): 756-62. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katyare, SS "Insulin status-dependent alterations in lipid/phospholipid composition of rat kidney microsomes and mitochondria." Lipids 41, 9 (2006): 819-25. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katyare, SS "Differential pH sensitivity of tissue superoxide dismutases." Indian journal of clinical biochemistry : IJCB 21, 2 (2006): 129-33. [PubMed Link] |
  • Patel, SP ; Katyare, SS "Effect of alloxan-diabetes and subsequent treatment with insulin on lipid/phospholipid composition of rat brain microsomes and mitochondria." Neuroscience letters 399, 1-2 (2006): 129-34. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katyare, SS "A comparative study of reactive oxygen species (ROS) related parameters in rat tissues." Indian journal of clinical biochemistry : IJCB 21, 1 (2006): 48-53. [PubMed Link] |
  • Patel, SP ; Katyare, SS "Insulin-status-dependent modulation of FoF1 ATPase activity in rat kidney mitochondria." Archives of physiology and biochemistry 112, 3 (2006): 150-7. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katyare, SS "Insulin-status-dependent modulation of FoF1-ATPase activity in rat liver mitochondria." Lipids 41, 7 (2006): 695-703. [PubMed Link] | [ Full text ]
  • Billimoria, FR ; Katyare, SS ; Patel, SP "Insulin status differentially affects energy transduction in cardiac mitochondria from male and female rats." Diabetes, obesity & metabolism 8, 1 (2006): 67-74. [PubMed Link] | [ Full text ]
  • Katyare, SS ; Patel, SP "Insulin status differentially affects energy transduction in cerebral mitochondria from male and female rats." Brain research bulletin 69, 4 (2006): 458-64. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katyare, SS "Effect of alloxan diabetes and subsequent insulin treatment on temperature kinetics properties of succinate oxidase activity in rat kidney mitochondria." The Journal of membrane biology 213, 1 (2006): 31-7. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katyare, SS "Differences in kinetic properties of cytochrome oxidase in mitochondria from rat tissues. A comparative study." Zeitschrift fur Naturforschung. C, Journal of biosciences 60, 9-10 (2005): 785-91. [PubMed Link] | [ Full text ]
  • Patel, SP ; Katewa, SD ; Katyare, SS "Effect of antimalarials treatment on rat liver lysosomal function-Anin vivo study." Indian journal of clinical biochemistry : IJCB 20, 1 (2005): 1-8. [PubMed Link] |
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