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- About
- Education
- Research
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- scott.gordon@uky.edu
- Office Phone: 859-323-8134
- 741 South Limestone, BBSRB room B259
- National Institutes of Health, NHLBI
- Postdoctoral fellowship
- University of Cincinnati College of Medicine
- Ph.D. - Pathobiology and Molecular Medicine
- State University of New York College at Brockport
- B.S. - Biological Sciences (Minor: Chemistry)
The Gordon lab studies metabolism and atherosclerotic cardiovascular disease in two primary lines of investigation:
Mechanisms regulating dietary fat absorption by the intestine.
- Genes that control chylomicron secretion.
- The influence of fat absorption on body weight, metabolism, and atherosclerosis.
Inflammatory protease activity in the artery wall and suppression by lipoproteins.
- Natural mechanisms of inflammatory regulation involving lipoproteins.
- Development of lipoprotein-targeting protease inhibitors.
Research techniques:
- Mouse models for atherosclerosis and intestinal lipid absorption studies.
- Cell culture including genetically altered cell lines and transendothelial transport experiments.
- Genetic manipulation using CRISPR.
- Confocal microscopy including immunofluorescence.
- Electron microscopy.
- Molecular biology: PCR, quantitative real-time PCR, agarose gel electrophoresis, mouse genotyping.
- Next-generation sequencening: RNAseq gene-expression analysis.
- Protein expression techniques: SDS-PAGE, western blotting, immunohistochemistry.
- Mass spectrometry: Proteomics and structural cross-linking.
See Dr. Gordon's profiles on:
PubMed
ResearchGate
Google Scholar
Selected Publications:
Resolution of Lipoprotein Subclasses by Charge Detection Mass Spectrometry (2018) Corinne A Lutomski, Scott M Gordon, Alan T Remaley, Martin F Jarrold. Analytical Chemistry. PMID: 29756771
Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux (2018) Rafique M Islam, Mohsen Pourmousa, Denis Sviridov, Scott M Gordon, Edward B Neufeld, Lita A Freeman, B S Perrin, Richard W Pastor, Alan T Remaley. Scientific Reports. PMID: 29440748
High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis (2017) Scott M Gordon and Alan T Remaley. Atherosclerosis. PMID: 28242049
The Changing Face of HDL and the Best Way to Measure It (2017) Sotirios K Karathanasis, Lita A Freeman, Scott M Gordon, Alan T Remaley. Clinical chemistry. PMID: 27879324
Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr-/- mice (2017) Zhi-Hong H Yang, Scott M Gordon, Denis Sviridov, Shuibang Wang, Robert L Danner, Milton Pryor, Boris Vaisman, Yuka Shichijo, Nobushige Doisaki, Alan T Remaley. Atherosclerosis. PMID: 28486149
Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease (2017) W S Davidson, Anna Heink, Hannah Sexmith, Lawrence M Dolan, Scott M Gordon, James D Otvos, John T Melchior, Deborah A Elder, Jane Khoury, Esmond Geh, Amy S Shah. Journal of lipid research. PMID: 28743729
Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome (2016) Scott M Gordon, Hailong Li, Xiaoting Zhu, Patrick Tso, Catherine A Reardon, Amy S Shah, L J Lu, W S Davidson. Journal of proteomics. PMID: 27385375
The effects of apolipoprotein B depletion on HDL subspecies composition and function (2016) W S Davidson, Anna Heink, Hannah Sexmith, John T Melchior, Scott M Gordon, Zsuzsanna Kuklenyik, Laura Woollett, John R Barr, Jeffrey I Jones, Christopher A Toth, Amy S Shah. Journal of lipid research. PMID: 26908829
A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins (2015) Scott M Gordon; Hailong Li; Xiaoting Zhu; Amy S Shah; L J Lu; W S Davidson. Journal of proteome research. PMID: 25894274
Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties (2015) Scott M Gordon, Benjamin McKenzie, Georgina Kemeh, Maureen Sampson, Shira Perl, Neal S Young, Michael B Fessler, Alan T Remaley. Molecular & cellular proteomics. PMID: 26483418
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice (2013) Maarit Lehti, Elizabeth Donelan, William Abplanalp, Omar Al-Massadi, Kirk M Habegger, Jon Weber, Chandler Ress, Johannes Mansfeld, Sonal Somvanshi, Chitrang Trivedi, Michaela Keuper, Teja Ograjsek, Cynthia Striese, Sebastian Cucuruz, Paul T Pfluger, Radhakrishna Krishna, Scott M Gordon, R A Silva, Serge Luquet, Julien Castel, Sarah Martinez, David D'Alessio, W S Davidson, Susanna M Hofmann. Circulation. PMID: 24170386
Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies (2013) Scott M Gordon; Jingyuan Deng; Alex B Tomann; Amy S Shah; L J Lu; W S Davidson. Molecular & cellular proteomics. PMID: 23882025
The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth (2013) Scott M Gordon, W S Davidson, Elaine M Urbina, Lawrence M Dolan, Anna Heink, Huaiyu Zang, L J Lu, Amy S Shah. Diabetes. PMID: 23835332
High density lipoprotein: it's not just about lipid transport anymore (2011) Scott M Gordon, Susanna Hofmann, David S Askew, W S Davidson. Trends in endocrinology and metabolism. PMID: 21067941
Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography (2010) Scott M Gordon, Jingyuan Deng, L J Lu, W S Davidson. Journal of proteome research. PMID: 20718489