- 741 South Limestone Street, Biomedical/Biological Sciences Research Building, Rm: 248D, Lexington, KY 40536-0298
BS: University of California - Los Angeles, 2013
I was raised in Los Angeles and attended UCLA as a biochemistry major before joining the MD/PhD program at the University of Kentucky. I came to Kentucky because the University of Kentucky overall has a large and diverse pool of faculty that would allow me to find both a mentor with similar research interests and other faculty who can provide valuable insight from outside my field.
My current research focuses on the role of the renin angiotensin system (RAS) in pathogenesis of aortic diseases. RAS is a well-studied endocrine and paracrine pathway with numerous FDA-approved, safe, and effective modulators; there is great promise in developing non-invasive medical treatments to address aortic diseases, which currently can only be definitively treated by surgical repair alone.
UKY CCTS PSMRF - July 2015
- Daugherty, A.;Chen, Z.;Sawada, H.;Rateri, D.L.;Sheppard, M.B. "Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?" Journal of the American Heart Association 6, 1 (2017): [PubMed Link] | [ Full text ]
- Tian, J.;Dang, H.;Nguyen, A.V.;Chen, Z.;Kaufman, D.L. "Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice." Diabetes 63, 9 (2014): 3128-34. [PubMed Link] | [ Full text ]
- Tian, J.;Dang, H.;Chen, Z.;Guan, A.;Jin, Y.;Atkinson, M.A.;Kaufman, D.L. "γ-Aminobutyric acid regulates both the survival and replication of human β-cells." Diabetes 62, 11 (2013): 3760-5. [PubMed Link] | [ Full text ]